As Upneeq stimulates Muller’s muscle and elevates the upper eyelid more of the eye is exposed and more evaporation of the tears is possible and dry eyes may be exacerbated. If you have significant side effects including any of the below, be certain to notify your prescribing doctor and your general doctor as soon as possible.
Alpha-adrenergic receptor agonists as a class may impact blood pressure. Patients with cardiovascular disease, orthostatic hypotension, and/or uncontrolled hypertension or hypotension should seek medical care if their condition worsens.
Patients with cerebral or coronary insufficiency or Sjögren’s syndrome should seek medical care if signs and symptoms of potentiation of vascular insufficiency develop.
Patients should seek immediate medical care if pain, redness, blurred vision and photophobia occur (signs and symptoms of acute angle closure).
Common adverse reactions (incidence 1-5%) include punctate keratitis, conjunctival hyperemia, dry eye, vision blurred, instillation site pain, eye irritation and headache.
